By H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)
This quantity offers in particular with these antituberculosis medications which handed the preclinical section and feature been or are utilized in the therapy of tuberculosis and different mycobacterial illnesses (except leprosy) in a minimum of a few components of the area. regardless of this restrict, there are 14 such medicinal drugs, and hence this quantity has reached relatively huge proportions. to avoid it from turning into even higher and extra unwidely, so much derivatives of antituberculotics were passed over, specially the place it really is claimed that they supply purely greater bioavailibility or tolerability. purely within the bankruptcy at the chemotherapy of illnesses because of so-called extraordinary mycobacteria is the scientific use of the medication defined to a definite volume. as well as antituberculotics, additionally mentioned are antimicrobials that have been came upon to be potent opposed to those mycobacteria. The series within which the medicine are defined is historic, reflecting no longer the time of discovery yet relatively the 1st scientific software. This order was once chosen for purposes that are now now not correct. during this quantity much less emphasis is put on detection, organic or artificial creation of antituberculotics, and structure-activity relationships. against this, emphasis is wear the measure, style, and mechanism of antimyco bacterial task, pharmacokinetics, and biotransformation in animals and guy, on experimental pharmacodynamics, and at the toxicity of antituberculotics used therapeutically.
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Extra resources for Antituberculosis Drugs
The macro-organism can be replaced by cell cultures for the study of some aspects, in particular for studies of the effect of antituberculotics on phagocytosed, intracellularly located tubercle bacilli. However, this technique too has some drawbacks, which must be borne in mind in an evaluation of the data. The various types of experiments - in-vitro tests, animal experiments, and cell cultures - are designated as models because the various experimental components can be modified to evaluate their importance for the test outcome and their relevance for the treatment of human tuberculosis.
Reviews by KRUGER-THIEMER (1956), OFFE (1956), and BERNSTEIN et al. (1953a, b) show that although some derivatives do approach INH in activity and exhibit one advantage or another, on the whole isoniazid is superior to them all in activity. References Behnisch R, Mietzsch F, Schmidt H (1948) Verfahren zur Herstellung von Thiosemicarbazonen. DBP 927:505 Bernstein J, Lott WA, Steinberg BA, Yale HL (1952) Chemotherapy of experimental tuberculosis. V. Isonicotinic acid hydrazide (Nydrazid) and related compounds.
It was discovered and isolated in the Biochemical Research Laboratories of Chas. Pfizer and Co. Inc. (KANE et al. 1950/51). OTC is produced by Streptomyces rimosus. In the initial isolation, a culture filtrate of the microorganism was extracted with n-butanol and transferred into dilute acid to give a crude concentrate. Chromatography on Florisil yielded a high potency fraction which was purified further by extracting into butanol and re-extracting into dilute acid. Pure crystalline OTC dihydrate was obtained by dissolving the crude material in dilute acid adjusting to neutrality with alkali and repeating this procedure (REGNA and SOLOMONS 1950/51).
Antituberculosis Drugs by H. A. Offe (auth.), Professor Dr. med. Karl Bartmann (eds.)
Categories: Nonfiction 11