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By D. Janz (auth.), Professor Dr. Hans-Hasso Frey, Professor Dr. Dieter Janz (eds.)

ISBN-10: 3642695183

ISBN-13: 9783642695186

ISBN-10: 3642695205

ISBN-13: 9783642695209

Epileptic issues desire therapy for a few years or perhaps for all times, and this makes an intensive figuring out of the pharmacokinetics and attainable risks and unintended effects of the medicine utilized in therapy vital. in the course of fresh a long time our wisdom during this box has significantly elevated, no longer least end result of the improvement of particular and delicate tools for the choice of anti­ epileptic brokers in organic fabric. The medical pharmacology of this team of gear has been studied commonly and will at the present time be considered as good proven. this doesn't unavoidably suggest that drug therapy of epilepsy is without difficulty. for instance, it has lately been proven that one of many more recent anti­ epileptic medications, greeted with nice enthusiasm via clinicians, might in infrequent situations set off severe harm to the liver and the pancreas, and turns out even to have a definite teratogenic strength. medical difficulties may be understood as a problem to the experimental pharmacologist, who should still attempt to locate reasons for the medical dangers, and, if attainable, exhibit new ways that greater medications may be built. lately curiosity has inquisitive about the significance of the inhibitory transmitter 'l'-aminobutyric acid (GABA) within the pathophysiology of epilepsy, and there were a chain of makes an attempt to discover valuable antiepileptic medications between components interfering with GABA metabolism within the CNS.

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It is worth noting that it is higher in children and institutionalized patients than in a neurological patient sample (JANZ 1969). 5% in monozygotic twins and a concordance of 6% in dizygotic twins (LENNOX 1960). In the literature there are reports of a number of homologous cases in siblings and also in the ascending line (BARSLUND and DANIELSEN 1963; ANDERMANN and METRAKOS 1969; BRAY and WISER 1965; DALY and BICKFORD 1951; GIBSON 1959/60; JENSEN 1975; LENNOX 1960; MATTHES 1961; NEWMARK and PENRY 1980; RODIN and WHELAN 1960).

The prognosis cannot, however, be considered generally unfavorable as a third of cases become seizure free after 4 years (KRUSE 1968). While transition from West syndrome to Lennox syndrome is not unusual (YAMATOGI and OHTAHARA 1981), transitions from Lennox syndrome to Friedmann syndrome appear to be the exception (JANZ 1969; KRUSE 1968; LAGENSTEIN 1977; OLLER-DAURELLA 1976; RARE 1961). From the etiological point of view, too, the Lennox syndrome comes between West's syndrome and the Friedmann syndrome.

By this we understand clonic jerks in a limited area occurring more or less continously over a prolonged period without impairment of consciousness. The state can occur in isolation but is frequently accompanied by Jacksonian seizures or by grand mal seizures which precede, interrupt, or follow it (for EEG see Fig. 15 c, Chap. 2, this volume). Speech disturbances of prolonged duration with epileptic discharges in the EEG above the temporal region of the dominant hemisphere have also been described as a status of dysphasic or aphasic seizures (GERSTLE DE PASQUET et al.

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Antiepileptic Drugs by D. Janz (auth.), Professor Dr. Hans-Hasso Frey, Professor Dr. Dieter Janz (eds.)


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