By Pekka Lappalainen
The actin cytoskeleton performs a imperative position in lots of mobile strategies together with phone motility, cytokinesis, endocytosis and phagocytosis. The constitution and dynamics of the actin cytoskeleton is regulated by way of a good number of proteins that have interaction with monomeric and/or filamentous actin. Actin monomer binding proteins presents a complete view on actin monomer-binding proteins and the mechanisms during which they give a contribution to actin dynamics and numerous actin-dependent mobile approaches. This new identify includes chapters that describe the fundamental mechanisms of actin dynamics in addition to the structural rules wherein a variety of actin-binding proteins engage with actin.
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Extra info for Actin-Monomer-Binding Proteins
134), and it is likely that the establishment and maintenance of neuronal cell polarization requires modiJation of AC activity at nearly every stage. AC Proteins in Apoptosis We have seen that AC-mediated actin cytoskeleton rearrangements are essential in many processes involving changes in cell morpholoey. This theme seems to persist in morphological changes that occur during apoptosis as well, ^^"^^^ although the precise mechanisms remain unclear. In some cell types, active cofilin colocalizes with actin in highly motile apoptotic membrane blebs.
Illustrations were made in Molsoft ICM Browser. should be of interest. The principal features of the profilin fold are also found in the endosomal adaptor protein p l 4 and in members of a snare subfamily, the longins, which indicates that these proteins may express some of the functions of profilin. ' Poly-(L-Proline) and Profilin The discovery that profilin binds poly-(L-proline) was used to develop a fast procedure for the isolation of profilin and profiliniactin based on affinity chromatography on poly-(L-proline).
FEBS Lett 1996; 399(1-2):117-121. 73. Edwards D C , Gill G N . Structural features of LIM kinase that control effects on the actin cytoskeleton. J Biol Chem 1999; 274(16):11352-11361. 7A. Toshima J, Ohashi K, Okano I et al. Identification and characterization of a novel protein kinase, T E S K l , specifically expressed in testicular germ cells. J Biol Chem 1995; 270(52):31331-31337. 75. Toshima J, Koji T, Mizuno K. Stage-specific expression of testis-specific protein kinase 1 (TESKl) in rat spermatogenic cells.
Actin-Monomer-Binding Proteins by Pekka Lappalainen
Categories: Molecular Biology